Metabolic Control Analysis in Theory and Practice
نویسنده
چکیده
. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 22 I . INTRODUCTION . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 22 I1 . MODERN THEORIES OF METABOLIC CONTROL . . . . . . . . . . . . . 24 111 . ESSENTIALS OF METABOLIC CONTROL ANALYSIS . . . . . . . . . . . 26 A . Scope of Metabolic Control Analysis . . . . . . . . . . . . . . . . . . . . 26 B . Elasticity Coefficients or Kinetic Orders . . . . . . . . . . . . . . . . . . 29 C . Enzyme Kinetics Viewed From Control Analysis . . . . . . . . . . . . . 33 D . Control Coefficients . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 35 E . Summation Relationships . . . . . . . . . . . . . . . . . . . . . . . . . . 37 G . Connectivity Relationships . . . . . . . . . . . . . . . . . . . . . . . . . 40 H . Response coefficients: The Partitioned Response . . . . . . . . . . . . . 42 V . CONTROL AND REGULATION . . . . . . . . . . . . . . . . . . . . . . . . 47 VI . MECHANISMS OF REGULATION . . . . . . . . . . . . . . . . . . . . . . 51 B . Interconvertible Enzyme Cascades . . . . . . . . . . . . . . . . . . . . . 53 F . Relationshipbetween Elasticities and Control Coefficients . . . . . . . . 38 IV . CONTROL-PATTERN ANALYSIS . . . . . . . . . . . . . . . . . . . . . . . 43 A . Metabolite Channeling . . . . . . . . . . . . . . . . . . . . . . . . . . . 51 Advances in Molecular and Cell Biology Volume 11. pages 21.64 . Copyright
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